In people with this condition, renal sodium is transported improperly despite normal adrenal and thyroid function. As a result, cellular volume depletes the kidneys excrete an excessive amount of sodium, causing dehydration and hyponatremia. This is a rare form of dysautonomia. CSWS can be confused with syndrome of inappropriate antidiuretic hormone, SIADH, but the rise in the antidiuretic hormone combined with normal blood volume is a key distinction of the latter. Because CSWS affects electrolyte balance, close to half of all affected individuals are at risk of a stroke.

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