Diabetic amyotrophy has a very high chance of spontaneous recovery, wherein the affected individual gains back almost all function. Pain is the first symptom to improve. This can happen in a few weeks after the first appearance of symptoms, or it can take up to a year. Weakness dissipates between three and four months after symptom onset, but severe cases may require up to three years of recovery. Most people experience a nearly complete recuperation while a small minority require ambulatory aids or wheelchairs.

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