A muscle can become tired and cramp up when overused. A nocturnal leg cramp that tightens up at night while lying still, for instance, could be due to a long period of inactivity or, ironically, overuse of a muscle. A lack of electrolytes, water, or other minerals can irritate muscles, which can also lead to spasms. When a muscle fails to receive adequate blood supply, contractions can occur when the muscles are suddenly asked to become active.
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