Most muscle cramps are benign and subside fairly quickly. However, some muscle spasms indicate a more serious underlying condition. If someone experiences muscle cramps along with red eyes, swelling, and discolored skin, they could have developed a blood clot. While not always dangerous, blood clots can break off from their original location and move into the heart or the brain, causing severe complications. When painful cramping lasts for more than 15 minutes, with subsequent soreness continuing for days, it is a good idea to consult a physician. It is possible the limb is receiving an inadequate blood supply or that a nerve has become pinched.

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