Over time, severe excoriation disorder can have several serious complications. Because it increases the likelihood of developing infections, it may also lead to tissue damage and sepsis. Records exist of cases so severe that the affected individuals require skin grafts. In some instances, excoriation disorder can become life-threatening. For example, a 48-year-old woman picked through the skin of her neck, exposing her carotid artery. Many people who have this disorder develop severe scars and other blemishes. Excoriation disorder may also cause significant back and neck pain due to the positions a person must take to satisfy specific picking impulses.

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