The HPA axis consists of the hypothalamus section of the brain and the pituitary and adrenal glands. Researchers have linked this axis to many conditions, including depression. Over 60% of people with depression show signs of an HPA issue, such as excess cortisol. Clinical trials using vitamin C, omega-3 fatty acids, and polyphenol-rich foods have had promising effects on cortisol levels. Foods like pomegranates and dark chocolate could be effective options for managing HPA-related depression symptoms.

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