Behavioral issues are present in over half of children with fragile X syndrome, and they are not in proportion to intellectual challenges. This means the same level of cognitive impairment in children with other developmental disorders may not cause such severe behavioral issues. Behavioral symptoms occur in clusters. Symptoms similar to those associated with attention-deficit disorders are present in 80% of people with FXS. These include hyperactivity, inattentiveness, restlessness, and impulsive decisions. Aggressive and self-harming behaviors are common and related to rapidly changing emotions, irritability, and the inability to regulate anger.

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