DiGeorge syndrome can also affect the thymus, a gland that stores T-lymphocytes, or T cells, which are part of the immune system responsible for protecting against illness. More specifically, some directly kill viruses while others work with B-lymphocytes to become antibody-producing cells essential for staying healthy. People with DiGeorge syndrome affecting the thymus are at risk for fungal, viral, and bacterial infections and autoimmune diseases. Some may have a small or missing thymus while others may only have a minor deficiency.

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