Many researchers wish to discover more about chimerism, but ethical and legislative complications prevent the studies. Human trials fall under strict regulations and guidelines. Additionally, the unknown risks of experimenting with chimerism pose a danger to human subjects. However, using an animal subject is also controversial. Some individuals believe genetic mixing and altering is ethically wrong. Several countries have laws that ban or heavily restrict these studies using human cells. The U.S. Senator Samuel Brownback introduced The Human Chimera Prohibition Act in 2005. The bill failed to make it into law and there has not been any further attempt to regulate chimera research in the United States.

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