Gastroparesis is comorbid (often existing alongside) with several diseases and disorders, particularly those affecting the endocrine, nervous, and muscular systems, as well as the connective tissues. Comorbid conditions include hypothyroidism, scleroderma, and Parkinson's disease. Diabetes, the disease most frequently linked to gastroparesis, damages nerve cells. Damage to the vagus nerve in the digestive system results in the symptoms of gastroparesis.

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