Drugs called proton pump inhibitors (PPIs) can reduce gastric acid production and alleviate symptoms. By interfering with the ability of certain cells to secrete acid, PPIs can help people with Zollinger-Ellison syndrome avoid surgery. While people over 50 taking PPIs are at an increased risk for spine, wrist, and hip fractures, for most, the risk is minimal and the benefits outweigh the risks.

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