Successful surgical removal of a benign insulinoma cures nearly 90% of people, though the existence of multiple tumors can lead to recurrence. Persistent or recurrent hypoglycemia occurs in people with multiple tumors. About 2% of people will develop diabetes mellitus after surgery. This is usually related to how much of the pancreas the doctor had to remove. If the insulinoma is malignant, 24% of people live for at least five years after treatment.

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