DVT patients often complain of localized fatigue. They feel that their limbs are very tired with or without exertion. This fatigue is different from muscle soreness caused by overstraining or leg pain that comes from sprains and injuries. Instead, the tired legs feel weighty and immobile, with patients being averse to moving them too much for any purpose. Someone with DVT may experience localized fatigue before any other symptoms appear. However, it usually goes unnoticed. Additionally, this feeling of tiredness in limbs often persists after treatment and recovery, especially in those having a weaker immune system.

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