Most patients who have Crohn's disease complain of being victim to extreme fatigue that interferes with daily functioning and activity. They report feeling lethargic and tired, often after hours of rest. Physical exertion also becomes hugely draining, and fatigue-related behavioral tendencies such as irritability and lack of concentration are common. The enduring fatigue and weakness that Crohn's diseases causes can be attributed to three things. Firstly, the immune system and other organs work overtime to maintain routine bodily process which leads to exhaustion. Secondly, anemia is a systemic byproduct of this condition which further depletes energy reserves. Lastly, Crohn's disease is known to cause depression, anxiety, and insomnia, all of which are conditions associated with fatigue.

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