Despite ongoing research, physicians and researchers are still unaware of the cause of Shy-Drager syndrome. This is partly because the disease occurs at random. What physicians do know is that the disorder features an accumulation of the protein alpha-synuclein in the glial cells that assist the brain’s nerve cells. Interestingly, these accumulations are also present in Parkinson’s disease, but in the nerve cells themselves. It is possible that the alpha-synuclein protein holds the answer to the cause of both diseases.

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