Individuals with mild secondary polycythemia may not have any symptoms, while others may experience headaches, fatigue, stomach discomfort, dizziness, blurred vision, high blood pressure, and periods of confusion. Other symptoms of the condition include tingling or a "pins and needles" sensation in the feet, legs, hands, and arms, bleeding problems, such as bruising and nosebleeds, breathing difficulty, chest pain, ringing in the ears, and weakness and muscle pain. In some cases, people with secondary polycythemia also suffer from gout, which causes joint pain, swelling, and stiffness, and red, itchy skin, especially following a shower or bath.

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