Leriche's syndrome or aortoiliac occlusive disease is a group of symptoms that develop due to peripheral arterial disease in the legs. The French surgeon Rene Leriche first studied and described the condition, which obstructs blood flow in the abdominal aorta of the stomach before this largest artery splits into the iliac arteries to both legs. The blockage interrupts blood flow to the legs and kidneys and also interferes with blood flow to the genitals.
The occurrence of peripheral artery disease or PAD increases with age and it is most common in older populations, but Leriche's syndrome (LS) can occur in younger people. Men have a higher risk overall for both PAD and LS. Other risk factors include diabetes, renal disease, and hyperlipidemia, a general term for high levels of lipids, such as cholesterol or triglycerides, circulating in the blood.
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