The cause of Henoch-Schonlein purpura is not clear. HSP most often occurs following a bacterial or viral infection such as an upper respiratory infection, chicken pox, or strep throat. Cold weather, insect bites, food allergies, and medication have also been found to trigger the antibody's attack on the blood vessels. In spite of knowledge of these predisposing factors, experts still do not entirely understand why the immune system responds abnormally in people with HSP.
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