As Kaposi’s sarcoma spreads, it can cause several complications. The most common are secondary malignancy and secondary infections. In some instances, it develops into lymphoma, a cancer of the lymphatic system. As fluid accumulates in the legs, people experience swelling and intense pain, which may lead to skin infections. If the tumors spread in the internal organs, such as the lungs or gastrointestinal tract, bleeding is common. This can be fatal.

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