In some cases, doctors order a biopsy to support a diagnosis of hypereosinophilic syndrome. Heart tissue biopsies are most common. Bone marrow samples can detect leukemia, a secondary condition of HES. The presence of abnormal cell growth in bone marrow biopsies may indicate the patient requires more aggressive treatment. Skin biopsies can help rule out other conditions with similar symptoms, such as vasculitis and T-cell lymphoma.

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