Swelling in the leg, usually the calf, is a common sign of a blood clot in a deep vein in the leg. The swelling is caused by obstruction of blood flow back to the heart due to the clot. When one calf appears larger than the other, this raises concerns. In these situations, both standing or sitting for a long time may aggravate the swelling. Although a blood clot is not the only possible explanation for a swollen leg, it is wise to seek medical attention.

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