Sepsis is a systemic infection that affects the entire body. The strains of Salmonella responsible for typhoid fever are the most likely to cause sepsis, but systemic infection can occur with other strains too. Sepsis as a result of salmonellosis is most likely to develop in people with compromised immune systems. The bacteria can also escape the gastrointestinal tract if severe inflammation in the intestines causes a bowel perforation.

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