Under the cortex lies the medulla, which contains many structures. This section holds large blood vessels, as well as the sinuses that facilitate the flow of lymph. It also contains the medullary cords, structures that consist of lymphatic tissue and contain a variety of B cells, macrophages, and plasma cells. Sinuses separate the medullary cords and connect to the efferent lymphatic vessel. Though most lymph nodes possess a single efferent lymphatic vessel, some may have two.

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