Adrenal insufficiency is different from adrenal fatigue and can lead to disease. Cushing's syndrome results from an overabundance of glucocorticoid and can lead to obesity, type 2 diabetes, excessive hair growth, and depression. It produces stretch marks, both from weight gain and as a result of the thinning skin. Other adrenal diseases include tumors, which are generally benign and highly treatable. Addison's syndrome causes an autoimmune response that affects corticosteroid production. Left untreated, the condition can result in an adrenal crisis, which is a medical emergency.

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