Rarely, the bile ducts of the biliary tract can be obstructed, causing a blockage of bile and an accumulation of bilirubin in the bloodstream. The most common side effect of this is jaundice, skin or eyes with yellow coloration. There are many ways a bile duct can become obstructed, including cancer, physical trauma, cysts, and benign conditions that cause the bile ducts to narrow. The most common causes of bile duct blockages are gallstones.

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