Ulcers can lead to unintentional weight loss, due to symptoms like appetite loss, nausea, and vomiting. Alternatively, a person with a stomach or duodenal ulcer may gain weight. The abdominal pain experienced with an ulcer is caused by the stomach acid irritating the sore; eating typically relieves this irritation by acting as a buffer between the acid and the lining of the stomach, especially with duodenal ulcers. In spite of other gastrointestinal symptoms, a person may eat more to achieve this relief.

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