Several conditions beyond liver or bile duct disorders can lead to elevated bilirubin. Autoimmune hepatitis, a chronic disease where the immune system attacks the liver, causes inflammation and damage that can disrupt bilirubin processing. Without treatment, this condition may progress to cirrhosis or liver failure.
Certain medications can also impair liver function, raising bilirubin levels. Prescription antibiotics like erythromycin, tetracyclines, and amoxicillin, as well as over-the-counter pain relievers such as ibuprofen, naproxen, and acetaminophen, are common culprits. Reviewing medication use with a healthcare provider can help identify and manage these risks.

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