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Liver-related causes of high bilirubin include the following:

  • Liver infections, like hepatitis: Viral hepatitis comes in several forms. Hepatitis A and E typically cause short-term infections, while hepatitis B, C, and D can sometimes lead to chronic conditions. These infections inflame and damage liver cells, hindering the liver’s ability to process bilirubin.
  • Liver cirrhosis: Cirrhosis replaces healthy liver tissue with scar tissue, often resulting from hepatitis B or C, or long-term alcohol use. This scarring disrupts liver function, causing bilirubin to accumulate in the blood.
  • Alcoholic liver disease: This condition progresses through stages, including fatty liver disease, alcohol-induced hepatitis, and cirrhosis. At any stage, the liver’s ability to process bilirubin can be impaired, leading to elevated levels.

Abnormal high bilirubin test result with blood sample tube

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