Depending on the type of infection, physicians may prescribe antibiotics for PANDAS. The American Academy of Pediatrics recommends that children with the condition continue taking antibiotics for at least five years after the last attack or until they are 21. Children who do not respond to antibiotics and experience severe symptoms may be prescribed plasmapheresis, which removes harmful auto-antibodies from the blood. Other treatment options include steroids, behavioral therapies, and tonsillectomies.

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