Angioedema is a swelling under the skin that sometimes forms in conjunction with hives. Some medical professionals call angioedema "giant hives" for this reason. Targeting the deeper layers of your skin, the condition primarily affects the face, in particular, the lips. While frustrating, angioedema is harmless and don't leave any scarring or lasting marks. In rare cases, angioedema may be a symptom of a more serious underlying condition, but for the most part, the symptoms of angioedema fade in time.
Angioedema is typically the result of an allergic reaction. The inflammation occurs when your body produces too much histamine, making your blood vessels swell. Angioedema is a more severe reaction than hives, despite being similar in presentation. Some of the more common allergens that can result in hives or angioedema are latex and insect bites. That said, airborne allergies like hay fever and dust mites can bring it on, as well. Angioedema may also develop as a result of an autoimmune condition such as lupus, or as a result of leukemia.
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