Certain chemical substances released during the inflammatory process include bradykinin. Bradykinin causes the vascular wall to dilate, and the spaces between the endothelial cells become wider. This change allows fluid to leak from the blood into the tissues. It's also responsible for the feeling of pain in the affected area. Pain is important because it alerts the body to the presence of inflammation. Tenderness means that the area becomes painful on touch. The presence of visible signs of irritability can be useful in children who are too young to talk and express their pain.

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