If you have insomnia, your body secretes inflammatory cytokines at a higher rate than those who do not experience insomnia. During sleep, the body regenerates, and the immune system calms down. Lack of restorative sleep is a major promoter of inflammation. People with rheumatoid arthritis or other autoimmune disorders experience this when lack of sleep due to pain associated with their condition promotes further flare-ups and more pain.

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