Osteonecrosis is the death of bone tissue due to a loss of blood supply. The disease may affect one or multiple bones. Although osteonecrosis may originate in the hip, affecting the femur, it can affect the knees, shoulders, and ankles as well. Risk factors include long-term use of high-dose steroids and excessive alcohol intake, sickle cell disease, and trauma. Osteonecrosis most commonly occurs between the ages of 40 and 65. Men develop the disease more often than women.

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