Early diagnosis is essential to avoid further complications of Charcot foot. The condition can be difficult to diagnose through imaging tests alone, so a doctor's ability to recognize the signs and symptoms is key. A hot, red, swollen foot should be treated as Charcot foot until an alternative diagnosis is confirmed. Doctors will general combine an overall health check with x-rays, MRIs, or ultrasound to assess injuries and the status of the soft tissue. Nevertheless, sometimes doctors misdiagnose the condition as a bone infection, because the imaging results can look similar. An indium scan will assess the white blood cells in the bone and officially rule out infection. A temperature test can also be an indicator of Charcot foot.

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