Osteogenesis imperfecta or brittle bone disease is a condition caused by ineffective or a lack of collagen in the bones. Collagen helps make strong bones; without it, the bones become weak and easily broken. According to the National Institutes of Health, OI affects approximately 50,000 people in the United States. Current testing methods can diagnose OI in 90% of affected people, but there are no medications currently approved to treat osteogenesis imperfecta.
Osteogenesis imperfecta is an umbrella term for genetic conditions that adversely affect the bones and means "imperfect bone formation." There are eight types of OI. The most common and least severe is type I. Type II is the most severe, and frequently causes death at or shortly after birth. Types III, VII, and VIII are more severe, and IV, V, and VI tend to be more moderate.
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