There is a symptom called Darier’s sign—a specific skin reaction in people with cutaneous mastocytosis. In Darier’s sign, skin that is scratched or stroked will develop lesions—which are usually swollen, itchy, and red—due to the mast cell overload, which becomes hyperactive. People with both kinds frequently have episodes of very itchy skin, and they may develop hives. In some cases (usually in children) the skin will blister.
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