People who suffer from a folate deficiency often suffer from extreme fatigue or tiredness. This is not the exhaustion commonly experienced after a stressful day at work, or a long and strenuous sporting activity. The fatigue that comes from a lack of vitamin B9 or B12 drains the body of energy to a more severe degree. However, the fact that someone feels this way is no proof that they have a folate deficiency issue; it might be a symptom of some other illnesses. Only a blood test can confirm the connection between this condition and folate deficiency.

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