There are many possible physical causes of anorgasmia. Medical conditions such as diabetes and Multiple sclerosis can cause orgasmic dysfunction. Men who have had a prostatectomy are prone to the condition, as are women who have had a hysterectomy, genital mutilation, or childbirth trauma including an episiotomy. Injuries of the pelvis and spinal trauma that affects the nerves can make it difficult to reach orgasm, as can conditions that affect circulation, such as heart disease. Anorgasmia can also be a normal response to the hormonal and physical changes that come with aging.

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