Determining the right course of treatment requires identifying the underlying cause of high bilirubin levels. If the reason is known, the patient may be able to reduce bilirubin levels with lifestyle changes such as abstaining from alcohol, or via medical treatments. For example, the Kernicterus condition affects newborn babies, and treatment requires the babies be exposed to natural or artificial light sources to change bilirubin (which is light sensitive) to its water-soluble form so it can be flushed from the body. Some drugs cause evaluated bilirubin levels, so reducing or stopping that medication will lower levels.

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