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5. Fibrinoid Necrosis

Fibrinoid necrosis happens when an accumulated protein-like substance that looks like fibrin -- white insoluble fibrous protein -- leaks and combines with the antigen and antibodies in the walls of blood vessels. If the debris is not destroyed or reabsorbed, it attracts calcium salts and other minerals and becomes calcified. Malignant hypertension, preeclampsia, and immune reactions such as hyperacute transplant rejection are common causes of this type of necrosis.

what is necrosis

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