A person with a family history of Dupuytren's contracture is 60 to 70% more likely to develop the condition — it is the most common inherited connective tissue disorder. Because the exact cause of the disorder is unknown, it is impossible to tell which family members will develop it. The gene markers associated with Dupuytren's may appear in people who will never have connective tissue problems. They may sometimes appear in a person with no family history of the disorder, though these cases are usually less severe than the inherited variety.

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