Recently, doctors have begun using the enzyme collagenase to treat Dupuytren's contracture. The collagenase dissolves and weakens the hardened cords that limit movement of the fingers. The physician injects the serum into the palm or joint and has the patient return in 24 hours. The patient must wear gauze and elevate the hand during this time, to allow the collagenase to break down the tightened cord. After 24 hours, the doctor flexes the hand to snap the now damaged cord. The patient then uses a splint at night and performs physical therapy each day for up to four months.

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