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Granulomatosis with Polyangiitis (GPA) is a rare disease that is a form of vasculitis or inflamed blood vessels of the nose, throat, sinuses, lungs, and kidneys. First described in 1931 by a German medical student named Heinz Klinger, Granulomatosis with Polyangiitis usually affects people between the ages of 40 to 65. Granulomatosis with Polyangiitis is a severe disease and can lead to death if left untreated. It may appear suddenly, or it may develop over several months.

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1. Wegener's granulomatosis

You may occasionally hear GPA called Wegener's granulomatosis. This is because the disease was initially called Wegener’s arteritis, Wegener’s disease, or Wegener's granulomatosis. It was named after a German pathologist, Friedrich Wegener, who had three cases and recognized it as a different form of vasculitis. The name was changed to Granulomatosis with Polyangiitis or even GPA to remove any association with Wegener who was a Nazi war criminal.

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