The presence of neurofibromas is another classic manifestation of neurofibromatosis. Neurofibromas are tumors that are located anywhere on the body and have different shapes and sizes. Cutaneous tumors are dome-shaped, soft, fleshy, skin-colored or hyperpigmented, while subcutaneous tumors are firm and nodular. Usually, these tumors do not become apparent until puberty and may continue to grow in size and number throughout adulthood. Pregnancy is also another time associated with tumor growth acceleration.

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