Severe E. coli infections can produce a significant fever. If yours climbs above 102°F or isn't coming down, contact your doctor. Acetaminophen can help bring a fever down at home, and a cool shower may offer some relief — if you're too weak to stand, cold towels or ice packs work just as well. That said, a fever that lasts more than two days or reaches a high temperature needs medical attention, not just home treatment.

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