Adrenal insufficiency and adrenal fatigue are not the same. True adrenal insufficiency is rare and considered an official medical diagnosis. If the problem lies in the adrenal glands themselves, a doctor will diagnose Addison's disease, but adrenal insufficiency can also stem from diseases in the hypothalamus or pituitary gland, which signal the adrenal glands to produce and release necessary hormones. Proponents of adrenal fatigue as a diagnosis believe that the hormonal insufficiencies it causes are not quite as severe as with true adrenal insufficiency but cause significant symptoms nonetheless.

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