A layer of special epithelial cells line the intestinal tract. These cells link together by connecting to tight junction proteins, which act as gateways between the intestines and the bloodstream. Part of their job is to allow vital nutrients to pass while protecting the body from compounds that could cause disease. If a malfunction affects the tight junctions, a person can develop intestinal hyperpermeability or leaky gut. It's important to note that the concept of a leaky gut as a cause of disease is more theoretical than scientifically proven at this point.


1. Stomach and Bowel Conditions

Many symptomatic conditions affect the stomach and bowels and general digestion. Most of these symptoms also cause nausea and similar issues. Below are some of the more common conditions that affect the stomach and intestinal tract. However, these conditions may not be linked with a leaky gut and have other causes.

  • Gastric ulcers grow on the inside of the stomach and cause stomach pain, bloating, and heartburn.
  • Infectious diarrhea occurs when bacteria, viruses, or parasites create an infection in the digestive system.
  • Irritable bowel syndrome (IBS) has a variety of symptoms, though the most common are abdominal pain, excess gas, diarrhea, and constipation.
  • Crohn's disease is another inflammatory bowel disease that usually develops gradually. Its signs and symptoms include fever, fatigue, diarrhea, and mouth sores.
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