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Cushing's disease wreaks havoc with the body’s hormones -- specifically cortisol. Side effects of medication most frequently trigger this disease. Some immunosuppressant and anti-inflammatory drugs are the most common causes of Cushing's disease. However, it's important not to confuse Cushing's disease with Cushing's syndrome. Cushing's syndrome refers to various symptoms associated with excess cortisol, while Cushing's disease is another name for the pituitary gland tumor. Cushing's disease, on the other hand, is a serious and potentially lethal illness.

Since the disease can cause serious physical symptoms, individuals taking corticosteroid medications should inform themselves about various ways of protection from Cushing's disease. The illness affects up to 3 million people on an annual basis. It can also be inherited, but the chances of this occurrence are rather low. Cushing's syndrome is treated almost the same as cancer, with radiotherapy, chemotherapy, surgery, and drugs that inhibit cortisol. Since some conditions can lead to this illness, aside from the mentioned medications, a large number of individuals are at risk. Thus, it's important to know the ten most common signs of Cushing's disease.

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1. Pituitary Adenoma

Pituitary adenomas are tumors that take place in the pituitary gland. There are three distinct categories, depending on their severity: benign, invasive and carcinogenic. While most pituitary adenomas are harmless, about 35% are invasive, and 0.2% are cancerous. However, this condition accounts for up to 70% of Cushing's syndrome cases. Also, this sign is the one most closely related to Cushing's disease. The problem with this condition is that no matter the severity, it causes the over-secretion of cortisol. When compared to any other source of excess cortisol, pituitary adenomas are the biggest contributor to Cushing's overall.

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