Swelling of the veins is a common occurrence when a blood clot forms. When the clot develops on the leg, against a muscle, the swelling can be painful and is a good indication of a problem. The greater tissue density of such areas makes it more difficult for the body to remove blood clots that develop here. In most cases, blood clots in these locations will become larger and more painful over time. Sometimes, blood clots form in response to injury or trauma to a muscle or blood vessel. In fact, trauma is a leading cause of blood clots.

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