HFMD usually clears up on its own within a week. In the meantime, over-the-counter pain relievers can help with discomfort — but don't give children aspirin, which can trigger a rare but serious condition called Reye's syndrome. Children's acetaminophen or ibuprofen are safer choices, and numbing mouth sprays can also take the edge off. When in doubt, ask a doctor or pharmacist which option is best.

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